I have been playing with the savage 10 prior to the addition of the accutrigger, finally had to have my own. Mine is a SS/synth./accutrigger, scoped with a zeiss conquest and warne maxima rings. I have found several 1" area loads with smokeless powder and love shooting it. Last fall my load of 43.5gr IMR4759 under 250gr SST/MMP HPH24 sabot and W209 primer shoots MOA @ 23K MV. Thus far 6 deer have fallen to this load, 4 were bang flops, other 2 were a few staggered steps and longest shot LRF'd at 235yards. I have found in the Savage 10II's that IMR 4759 42-45gr under 250-300gr bullets is a good choice. It is reliable, accurate and light on recoil. I switched my load to a 300gr SST/MMP HPH24 under 68gr of H4198. This load also shoots MOA and 23K MV. Recoil compared to the same combo under 43gr of 4759 is a good step up.
Quirks include:
maintaining and replacing the ventliner. Life expectancy of the ventliner IME has to due with type of ventliner and powder/charge. I have found slower burning (non book loads) provide longer vent life, though they come with a price of more powder(cost per shot) and recoil.
Breech plug removal. To remove the breech plug on the savage without mods or aftermarket tools requires one to loosen the action screws to remove the bolt and use the supplied savage breech plug wrench. Failure to return the action to the same torque specs can result in POI shifts. Not a big deal if you plan to do a final site in and leave it till after the hunt to attend to the breech. Solutions to this problem are adding a 3rd pillar/bedding to keep the action mated for servicing the breech. Aftermarket tool called the EZ Tool RV, that allows you to remove/service the breech plug without removing the action screws or bolt (40 USD). "/lb torque driver to set the action screws to the same spec each and everytime.
Cooling between shots. I weight 5-10 min between shots before reloading. If really hot and or humid I wait even longer. This only applies to shooting for groups, in hunting applications the effect would not result in a missed animal in a quick follow up situation.
Primer and sabot preference have always been an issue with any ML I have owned and I personally don't see the savage to be more difficult in this regard. I use 209w's only on the premise of a supply on hand for my other ML's.
I love shooting my savage 10II, it is a hoot on the range, benefits of smokeless in the field are unmatched and far out weighs the quirks. It has been the easiest inline I have owned to get top level accuracy, right out of the box.