No.1 cartridge is the good old .22lr hp. next is .17hmr, last is .22wmr. Also have been known to use 12 and 20 gauge for close quarter defence. Not fussy about which .22lr, as long as it is hollow point, but not Remington Thunderbolt. I have shot thousands with Winchester 333, 555, W-W HP, Federal Blue box HP.
I like reloading, but not enough to fiddle around loading 1000's of small caliber. I have a nice old-time 22-250, built in 1947 by G.B. Crandall, that I might try sometime. It is a heavy barrel with an Unertl scope, so not exactly a light little gopher gun. I use a small folding stool and a camera tripod with a custom v-shaped rest (manufactured by my sidekick professional gopher shooter from Ontario).