Couple things you can do.
- Shoot a 5rnd group off a rest to eliminate as much shooter error as possible. Adjust sights if needed and shoot another 5rnd group. If they are patterning how you like them POA to POI, your gun is set. Shoot a 5rnd group unassisted, If your POI is off, then it's all shooter error.
- See Ganerite's reco above. If you can put a solid group together in the same area (ie all low left or all high right etc) then adjust sights to suit your shooting skill. This is like compensating for your shooting errors but at least you're consistent enough that the adjustment will work for you. Better yet, find out what is causing you to throw your shots and fix that instead so that you are capable of shooting any other handgun with some degree of accuracy based on your skill level as opposed to trying to compensate with an unfamiliar gun.
If your groups look like your target was shot with a blunderbuss (ie high right, low left, right, left, high, low with no consistent pattern), then you've got bigger fish to fry ie. you need to work on your technique.
Then again, that's just my 2cents.