Your choice between a SA and a DA can be either an emotional one or a practical one, but there is no wrong answer. From the emotional standpoint, which do you prefer the look of? From the practical standpoint which fits you hand better? The speed of ejection or the speed of the first shot means little if you can't control the recoil or hit your target. Balance is a function of barrel length, so get the feel of several before deciding. Weight tends to tame recoil, but felt recoil is another matter. Stock design and material play a huge role in felt recoil, and one of the most punishing .44s I've used was a long barrel Super Redhawk with the rubber grips and wood side panels, the older Redhawk with the solid wood grips worked much better for me. The hump on the S&W M-29 I find particularly painful when heavy recoil is involved, despite the fact to my eye its the best looking revolver ever built.
I've pretty much abandoned the idea of a big bore DA revolver. The SA fits my hand better and handles recoil better. In the case of my Vaquero, the SA has proven to be exceptionally rugged, which is an important consideration in view of the fact that I carry it as my wilderness ATC gun. If I was not concerned about the price, I'd consider a Freedom Arms gun with fixed sights and a short barrel. Now that Ruger has down sized the Vaquero, when my .44 needs to be replaced, I might be forced into the more expensive line if I I want to keep those features.
Speed of reloading I don't consider important, but while the DA must be taken out of action to dump its empties and reload, the SA can be continuously reloaded as each empty lines up with the loading gate; thus it never runs dry. Some make an issue of the difference in the rate of fire between a SA and a DA. Neither is this important with full powered loads, as it takes the same amount of time to recover from recoil and reacquire the target with either gun. During this time, either can be cocked for the follow-up shot or the DA shooter can begin to add pressure to the trigger as the gun comes down from recoil.