First of all, I bow to BIGREDD's expertise on this one. I do not know anybody that has shot even a small percentage of the slugs he has shot at game.
BUT
My own personal experience, with my own personal gun (Remington 870 Wingmaster 12 ga 2 3/4" chamber, smoothbore barrel) has consistently been that the Winchester 1 ounce slugs give me the best performance. That gun with that loading has killed about forty deer in my hands. With the scope that I now have on the gun, I can consistently put three rounds into three inches at 100 yards. With open iron sights, my groups were not as tight, but still minute of deer/minute of pie plate. I have killed deer at 100 yards and beyond with this round, but for sure those were at standing deer and sometimes they did not go down immediately.
The Challenger slugs will NEVER, EVER defile my chamber again, after their one disastrous season when I should have had my head read for forsaking a round that works.
Doug