I've hunted/shot squirrels, snowshoes, groundhogs, porcupines, raccoon, skunk with various muzzle loading rifles. Calibres .40, .45 and .50. A load of 50 grs of FFg and a patched round ball is a great small game load. Kills without blowing up any meat.
Also shot a lot of upland game birds and animals plus waterfowl (before steel shot laws) with various smoothbores.