It really has nothing to do with small/big hands, just how you prefer to grip and what's comfortable for you. I have tiny hands, and I shoot my full size HK45 way better than I shoot my PX4 in 9mm, or the G17 I had. I even have the larger of the 2 backstraps it came with on the HK45 just because I like the way it fills my palm. My suggestion is go to a gun store and fondle all the pistols you can, and maybe try some out at the range if people will let you.