I find it interesting to read of the trouble some have had with the TSX. I've yet to see that myself, but given time I suspect I will. But that's true of every bullet. Search around on this site, and you'll find one or two well documented horror stories of Accubonds or Interbonds coming apart on a deer's shoulder. Name a bullet, and someone's had one fail in one fashion or another. Shoot it enough, and you will too.
I do think the TSX has a very real and valuable role to play in the hunting field as a "shoot everything" bullet. On my first trip to Africa, I shot a whack of plainsgame (34 critters, I believe) with a .270 using 130 grain Interbonds. For the most part, the animals fell quickly. Exit wounds were rare. When they happened on smaller animals, the exits tended to be fairly dramatic. I still use that bullet exclusively in that .270 -- I've yet to see an Interbond fail to do what I expect of it, and for certain they put deer-sized game on the ground quickly.
However...
On my second trip to Africa, I carried an '06 loaded with 168 grain TSX pills for my plainsgame hunting. It was a very different experience compared to the Interbonds. When hit, the game did tend to run further -- though I don't recall anything running more than 70 or 80 yards. Exit wounds were the norm however, even when the shot angles were less than perfect or the animals were on the large side. Shots that would have been "iffy" with the Interbond were "gimme's" with the TSX. Yes, the animals ran further when hit -- but they still fell over reasonably quickly. And when shot with at TSX, the smaller critters were left in a state that kept the taxidermist happy.
For the time being at least, I still see the TSX as one of the very best options for a light rifle that will be asked to shoot game ranging from 30 pounds to over a thousand. Within that spectrum, there are certainly better bullets for some portion of it -- but there are few, if any, that can do as good a job over the entire range. I still load TSX bullets in that '06, as that load and rifle are near-perfect in how they fill the role of "shoot anything". They may not be the absolute ideal combination for any particular game animal, but they'll kill it with boring predictability. I like that. A lot.