I've shot animals with a 168 tsx several times now - big as moose and small as sitka. They're coming out at about 2850, so impacts were from about 2750 to about 2100.
Both opened and expanded exceptionally well. The slower long range shot was actually recovered - excellent petal, and the mess it made inside the chest cavity was exceptional. Bone was hit admittedly.
The closer shots (short as 30 yards, long as just over 100) shots opened up whether bone was hit or not.
I talked at length a couple times with a tech at barnes - he said barnes will perform very well between 3000 and 1800 fps. More than 3000 and you could start losing petals, tho it'll likely still do a number on the innards.