I don't pick a bulet. I let the gun pick it. I'll look at other's results, pick 3 of them most common performers, and grab 2 or 3 powders as well. From there, I'll start with the common "best loads" from various manuals, and load 5 of everything about 2 grains either way (without exceeding min/max loads) in .5 grain increments. Makes for a pile of 5 shot batches. (5 @ powder 1, x grains, bullet 1, 5@ powder 1, c grains, bullet 2, 5 @ powder 1, x grains bullet 3) - repeat for maybe 5or 6 powder weights per powder, for each bullet option. 3 powders, 3 bullets, 5 or 6 powder wieghts ... makes about 30 combinations for a 3 & 3 option ... 150 rounds total at 5 per option. Overkill? maybe ..
Then I wait for a nice calm day, take the gun out, and spend a few hours putting all the rounds down range. I take those targets home, and study them, and find the combination that seems to be pulling in the tightest before it starts opening again at the distance I am shooting, then I start working that bullet & powder combo from "close" to where it started openign up again in .2 grain increments.
Once I find the "best" I can get out of that, then I start tweaking OAL. During the preliminary testing, i try to stay around the 0.025 mark. At this point, I would now make 5 shot batches and movein 0.005 increments out to about 0.050 and as close as 0.010, while watching for pressure signs.
99% of what I do doesn't need a crimp, but if it did, I would toy with crimp pressure after toying with OAL.
Primers have never shown to make a difference to me, outside of some of my guns prefer a softer primer - my 22 hornet will occasionally give me issues with the harder primers. In theory, they will make a differnece, but in practice, I can take a known good load, and use any primer with it, and it will be just as accurate for my shooting abilities.
I've never had much time (or space) to work up any big bore (308 & up) long range loads ... mostly 243 & smaller stuff at 300 yards or less, but for serious longer ranges, I would be sorting cases by volume and working my loads up in an acceptable range of volumes (maybe a 2 to 5 grain of water spread over the cases used).
All that said, "minute of gopher" @ 200 yards is usually good enough unless a person gets a true sense of accomplishment watching their groups shrink on paper.