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One thing is that these sights sometimes do not want to fit in some holsters as they are too high. As for shooting with them, I noticed no problems, they are usually easier to see as they are higher than the normal sights.
i have them on my S&W M&P Pro CORE and they co-witness my red dot perfectly.
i also have them on my Glock 19 and i like them.
its probably just me, im getting older and my eyes find them much easier to use then the little nubs that come on a lot of guns.
and yes the ones on my Pro CORE do catch my holster that my other M&P's clear with no problem.
but i could easily just dremel it open more if it was that big of a concern.
Yeah I found out the hard way that my supressor sights no go into a number of my leather and kydex holsters so I went with Comp Tac which has a huge sight channel. I am sure newer models of other manufacturers account for this but worth checking before you buy a new holster.