I recently made just that decision, went with the S&W 22A, have had nothing but problems. When it shoots, it shoots very well, it is ammo sensitive, and i bought a dud. It is being sent back, the slide doesn't always cycle all the way closed and i get a light strike on the cartridge that doesn't fire.
My g/f bought a Ruger MKIII and hasn't had a hiccup with any type of ammo.
I am not a fan of how the Ruger looks, but it is definately more reliable.
Also, remember that mine has something wrong, right from the factory. I'm sure there are others that have no problems.....
Rob