The more I play around with the 375 Ruger, he more I see how effective it would be for one gun, anything , anywhere in the world. You would just need to have A few loads.
A full power 300gr Premium load @ 2500 fps for anything dangerous.
A full power 260gr Premium load @ 2750fps with a flat 30-06 liek trajectory for all other big game.
A full power 235gr load @ 2950fps to flatten trajectory for yotes and probably a great deer load.
A reduced load 200gr @ 1600fps for small game like grouse and plinking etc.
Mostly, you could hunt wih the 260gr load, keeping a few reduced loads in your pocket for grouse.
When predator seasons start, you could switch to the 235gr load.
I sure wouldn't suggest this for a beginner, there is an argument that this would be more versatile than the favorite "all around" cartridge, the 30-06.