The golden rule of handloading is that any time you make a change of component, primer, powder, case or bullet, you drop the powder weight and work back up to maximum. Having said that, both the Sierra and Hornady manuals lump 52 and 53 gr data into the same chart. If it was my rifle I would not drop the powder charge in this case. When I shot .222 and .22-250 the most accurate 52 gr bullet loads in my rifle were a grain or so below maximum. If you load your rounds to maximum pressure, then you should back off a bit for the heavier bullet.