Yes of course all of these high performance projects will be hard on barrels. That's not at all an insurmountable objection, the per-shot cost of a barrel is usually a lot less expensive than the per-shot cost of ammo.
What are you looking for? A good long-range hunting load, or a long-range target shooting load? Do you want a flat trajectory, or minimal wind drift, or lots of on-target energy?
(it sure is fun to explore all these "what-if"s....!)
If you are interested in target shooting (i.e. wind drift is what matters, all else is secondary), one problem with .30 calibre is that it does not have any super-duper high performance target bullets made for it at this time. The heaviest good .30 cal target bullets are only 210 grains (Sierra and Berger), it would be nice if one or more of the good bullet makers finally made a proper "heavy" .30 cal target bullet (230-250 grains, with VLD-like performance). Until this happens though, you might actually be better going with a high-capacity 7mm, since it has super-duper bullets (e.g. Berger 180 VLD class).