I bought a 10mm barrel for my Glock 21 and love it. I haven't had a chance to do any reloading for it yet but have run a few of my buddy's full power handloads through it and it was really nice. I have a spring kit and SS guide rod on order which should make it shoot even smoother.
I have been collecting brass and other supplies and haven't had much trouble finding anything. Brass can be a little tricky if you expect to just walk into any gun shop and grab a bag but it is readily available by mail-order. I bought 2 bags of Rem brass at Wholesale in Edmonton a while back though so if you keep your eyes open it is out there.
Factory loads are weak though so Handloading will be the best option.
I think a Gen 4 Glock 20SF will be one of my next pistols.
Whichever gun you get I'm sure you will like the 10mm as long as you aren't on an ammo budget.
Good luck