I've experimented with Trail Boss alot, but have no exp. with the .38, I have used it with good success in the .44/40, .45 Colt, 32/40, 38/55, and 45/70. In the .44/40 and the .45 Colt it is excellent and would make a great Cowboy action load. I am using 5.5 grs in the .45 Colt with 255gr. cast bullets from MT Chambers and have had great results. Trail Boss is bulkier than any other powder I have tried and 5.5 grs. fills the case more than other powders, so is not position sensitive and no fillers are used in any of these cases including the rifle carts. In the rifle carts. you use comparatively less powder and it does a great job of filling the case, however, pressure goes up quickly, before high vels. are reached. In my .32/40 using fixed ammo I could only reach 1100fps. before reaching my self imposed pressure limit for the circa. 1901 Win. 1885. This is a good powder if you want light loads(without ignition problems) and also save some money on powder due to light charges. Pls. note that I did not try to breech seat at all with this powder.