Johnn, I've got a couple loads ready for testing that use 5744, virtually identical in ballistics, to 4227. One is 25 grains of 5744 with TP filler and the other uses 28 grains of 5744 with no TP. They should give roughly the same velocity. So one of those loads falls nicely into your suggestion of 22-27 grains of 4227.
Regarding filler, I like your backer rod idea. At some point I'd like to experiment with different fillers, observing both E.S. and ease of reloading, and leading, and group size (consistency). There is a very nice product called poly filler that seems to be about perfect except that it is ridiculously expensive if you do a lot of shooting.
For me the only down side of using the backer rod is to start with, it was a little time consuming. I made up a little jig to use measuring & cutting the backer rod so now, the required time isn't an issue.
A target I have at the moment is one I shot with the Pedersoli, open sights and a good rest at 100 yds. The five shot group was 2.559", minus one as a flyer

, 1.385".
In my 'tattered' well used Lyman Handbook of Cast Bullets, the powders listed for that bullet weight are, Unique, 4198, 4759, 4227 and 2400. Velocities listed range from 1050 - 1470* f/sec. IMR 4227 has worked well for me with some of the lighter cast loads but I will get around to trying some of the other powders.
For the heavier jacketed loads, I've been primarily using IMR 3031 although another shooting friend, 303carbine, has had great results with IMR 4198. I've recently loaded a variety of jacketed bullets using 4198, now its a matter of getting out to the range and testing.
90% of my cast bullets I get from a local guy, with the exception of the 405gr. Those I picked up from another guy, not too far away.
Good luck. If you find something that works really well, post it and/or give me a shout.
