I was having a similar issue with my handloads in my custom rifle. Im very picky when it comes to loading, and I found out that my Lee powder dump was not consistently dumping varget into each bullet all of the time! I have extremely good results with finer powders, but it seems that the big stick powder will sometimes get stuck in the dump, resulting in a HUGE variation! So what i do now id give each loead a few light taps with a screwdriver to make sure nothing gets stuck in the dump.... It makes sure none of the grains get stuck. I need to upgrade and get a Hornady or RCBS electronic powder measure..... soon enough... ;-)