I've used Varget with Hornady 110gr V-Max, Sierra 110gr MatchKing and Barnes 110gr TSX, all with great accuracy.
My experience with Varget is that it's almost always accurate but loading density is low with 270 Win 110gr TSX and you should use H4350 instead (I almost blew up a rifle because of a faulty electronic scale with Varget and 110gr bullets)!!!
A 110gr V-Max is instant death on any varmint at any reasonable range and the 110gr TSX is deer dynamite (3400fps).
Alex