My first moose was with a 243, it's what I had, 17yrs old. Basic 600-650lb on the meat hooks BC interior Moose. Close range 《 80yds, behind the shoulder, but high. Needed a finishing shot. Crap imperial 100gr soft point.
It's a centerfire, at close range it's got the energy. Somewhere i have the bullet energy calculation formula. IIRC, it's bullet weight x velocity squared/ ????. Point is the velocity contributes, squared; whereas, bullet weight is linear. So keep the velocity high, premium bullet ( or shet house luck in my case) and keep the range short. Most of the moose I've shot have been close, bayonet distance to 100yds. I've just always hunted tight and swampy areas for swamp donkeys. Would it be my first choice, hell no, will it do it, yes in the right situation.