If you are looking for 22LR to sharpen your shooting skill, I would go for TC-Contender. This thing has a rifle accuracy. Do not know price lately, but expect to pay about half of the price for S&W 41.
For excellent pistol, as other suggested S&W 41. The only fly in the ointment; they are not cheap, even old ones.
For a very nice plinker, I like Browning Challenger II, look for one with adjustable sights. NOTE: Challenger II is the last one with steel frame, III and up are with aluminum one. Delight to shoot, not too heavy, IMHO, the best bang for the buck in 22LR. If you do not like heavy barrel pistol, this is the one to have.