Depends what kind of shooting you want to do.
If it's plinking you want to do, I know a couple guys that swear by the Norc Woodsman copy. Cheap, no worries on whatever you put through it, and you can knock it around however much you like.
The Rugers are nice because (at least with the MkII's) there are more accessories available for them than most other .22 self-shuckers. Yes, takedown is a pain but as Nine eloquently put, you get used to it. If not, there is an outfit in the US that makes a quick takedown kit. Regardless, the rugers are good because they can be used for plinking, or with a little work, perfectly good as an above average entry level pistol for bullseye.
The High Standards and Smith 41 are great as described.
Then you get into the higher end target guns which are not only more money to buy but more money to feed as you should use only standard velocity ammo (no HV Wallyworld hollowpoint bulkpak, due to lighter springs normally used): FAS Domino, Bakail, Matchguns, Morini, Hammerli, and of course my fav, Walther.
With the higher end guns, please take one piece of advice: the difference it will make in your shooting, unless you practice three or more times a week or are aspiring to try some ISSF competition (which I highly recommend for fun actually), is negligable. 10%, maybe 20% difference if you are really concentrating, or something on your previous gun was bugging you. The only thing the more expensive gun quickly does is make you realize it is the operator behind the trigger which is causing the problems - the same problems you were experiencing with the "lower quality" gun. The target guns are adjustable up the wazoo which is great for fine tuning the gun to yourself, but most of us need to work on the other 90% coarse basics first, like controlling breathing, focusing on the front sight, and applying even trigger pressure - the fundamentals with any pistol.
Therefore, IMHO for all around fun and possible future considerations, I'd recommend a Ruger .22 MkII or III in a 5.5" barrel with adjustable sights, and then buy an aftermarket trigger kit and target grip if you truely want to go for the gold.