My vote went to the G22, I have one and put a few mods to the gun and it shoots like a dream. The trigger pull now is 2.5-3 lbs and with new springs and a bunch of other little mods make it rocks. I have big hands as well do I prefer the full size and I'm a big fan of .40cal, I do have a lone wolf conversion barrel that allows me to shoot 9mm. Can't say enough positive things about this gun. I would love to try a g35 at some point.