It's good to put things in perspective here. Many would condemn the use of a 22-250 or 220 Swift on a deer, yet they might consider whacking a wolf with the same rifle quite alright. I do not consider the 22 centerfires a good choice for deer-sized game or anything larger, but have shot a few wolves that weighed over 100 lbs with the 220 Swift. Many deer do not outweigh these wolves, so why should a decent bullet out of these not work OK for them? As I stated, I would not deliberately hunt deer with a 22 CF unless it was all I had, but have killed a truckload of deer with the 6mm Remington. It pays to avoid "iffy" shots with the smaller bores, but they are capable of getting the job done. I do NOT like to put the 6mm's in the hands of a novice shooter to hunt deer, because they require a degree of precision often lacking in a new hunter. My kids all did their first hunting with the 6.5x55 or the 7x57, loaded to recoil levels they could tolerate. These are better rounds if a shot is a bit off the exact spot intended, a very real possibility with an excited newbie. I still grab the 6mm if I am on a doe draw, but prefer just a little more rifle for serious deer hunting where a big fellow may present himself out past 250 meters. My 270 or the 264 often get the nod, and the 6.5x55 has accounted for a fair number as well. Regards, Eagleye.