One caution I might add. I have a 32-20, 22 Hornet, 444, and 32 Special because I like unusual older cartridges. It has been challenging finding components, tooling, and prices for brass and availability can be a real pain, 221 Fireball, 218 Bee and 25-20 might apply here. My Hornet is in a H&R and a bit crude but a ton of fun. I do highly recommend the caliber. However, the brass is a little thin and delicate requiring some care and if you push it case life isn't optimal. My 32-20 is the same and its the parent case for the 25-20. If CZ made the 22 Hornet in a lefty I'd already have one. I love these interesting cartridges but thought you should note these factors.
But for ease of supply and availability the 223 shines if you want to handload down. Good used 222's are available and occasionally new CZ's can be found in that cartridge. It appeals to me but every cartridge I own is poorly represented on the shelves here in Calgary.