I have a very accurate Ruger v in 280. It’s taken moose bear and both species of deer ( in Ab). Never felt underguned and lots but not all 1 shot kills. A mule deer buck at 500 yds was a bang flop with 175 Nosler partitions. This is my very max snd he was standing in an opening. Bullet placement trumps all. Use a mid cal with enough energy for your max range and practice.