I guess it really depends on how far, and what the terrain is like. A couple of months ago I was hog hunting in Sask. All day I was going through brush, up hills, across fields, etc, etc. I used to carry rifles in the army all day, but, I was carrying a Remington 12 Guage express shotgun on this trip and it got heavy, and got to be a pain in the ass to manouver in the bush after three days. My solution for next year ? Nylon thumbhole stock/ with a fore-end, and a military style tac sling so it hangs at a natural angle in front of the body. I find the pistol grip stock is far easier to manouver in the bush, and its handy to have a sling to take the load off - and be ready for a quick shot - when you're brushing tree limbs out of your face.
I also have a Ruger M77, .308, for deer and larger game. I love it, but, after a few days of tramping around it also gets heavy. But, I just cant bear to ever sling a rifle over my shoulder. I always have to have it in front, I guess its an old habit, but would need to adjust if I ever hunted sheep or goats in the mountains or foothills.