In short Vaquero is a fixed sight version of the Blackhawk. Vaquero offers different finish - ie. gross polish steel and color case. Bisley models(when compare to Blackhawk) have different shape of grip frame, hammer and a heavier frame(all steel grip frame rather than alloy) - following the style of the first Bisley target revolver by Holland & Holland in England-I think. Ruger offers two lines of Bisley model - the Ruger Bisley and Vaquero Bisley(the difference is as above - adjustable sight vs. fixed sight, and finish). Oh, one more difference - Vaquero Bisley comes with fluted cylinder and Ruger Bisley comes with engraved unfluted cylinder.