Shooting with confidence beyond 350 yards or so requires a lot of shooting, an accurate rifle, and ideal conditions. I have shot several head of game out beyond 450 (longest shot 602 lasered yards) but in each case, I knew the distance within 5 yards or so, I had a broadside shot, and the wind was calm. I still feel more comfortable with shots inside 400, even though I know my rifles intimately, and have the trajectory of each out to 600 yards imbedded in my cortex firmly. It is a matter of plenty of practice at all ranges. (The books & charts are often way off actual drop figures) Obviously, as some have noted, a moose is a considerably larger target than a deer, so hitting the smaller animal is more challenging than is hitting the bigger one. I see some have set conservative limits for themselves....that is a good thing, and shows humility and good sense. As the skills improve, one can move the maximum out further. Regards, Eagleye.