I have both the 88 win in .308, and a .450 Marlin. Both the guns are excessively great shooters, but the .450 hits em like a runaway Mack in a 10% downgrade. If you are into handloading, as everyone has said you can beef up the 45/70. but nice to have the off the shelf performance of the .450, especialy in the new leverevolution ammo out now. My choice would be the .450 for exclusively moose or bear, but all round flexibility for deer sized animals too, the .308 in savage or Winchester or any BLR in equiv or short mags.