I have shot some game up to and including moose with the Hornady Interlocks with generally good results, as seen in Dennis' pic. Hornady bullets have always been superbly accurate in my experience. However, I did have one dramatic failure, using the 140 Interlock in one of my 270's. This may have beeen an abberration, but it was definitely something that surprised me. I shot a 4 point Whitetail buck broadside at about 80 yards. The bullet hit an onside rib, and it basically broke into 3 pieces. None of which hit a vital organ. Nonetheless, it stunned this deer, which then ran about 50 yards and stopped, looking back as if to say, What the h*** was that? Gave me a chance to put another one into him. This second bullet acted properly, and the result was a dead deer. The autopsy showed what had happened. One piece of the bullet was in the onside shoulder, one piece was in the flank and the last piece was somewhere in the gut. This bullet had a muzzle velocity of about 3000 fps, so wasn't a really fast load. Strange behavior, but enough to make me choose a different bullet for my 270. Regards, Eagleye