Funny, any split case I have ever experienced had an off tone to it when handled at one stage of the process or another - normally while picking cases out of my tumbler and dropping them into a bucket. Of course, those who use revolving screens, dump their cleaned cases into a case feeder, run them through a progressive loader at 400 cases per hour, and stuff loose loads into their guns may not handle cases at all!
I have fired pistol cases cracked at the mouth, and have read of deliberate tests of firing split cases in a revolver, all without incident, but good practice and an interest in being somewhat able to predict where the bullet holes may lie on a target would decree one really shouldn't!