Well, I'll agree that a .22LR is better than using a stick or harsh language, but if I had the choice I'd go with a centrefire of ANY kind (even a 25-20) over a .22LR.
If it's going to be for up close and personal work, like bush protection, and all he's got is a .22LR, I'd suggest some bullet mods like cutting an "X" with a knife blade in the tip of his hollowpoints to maximize early upset. This brutally affects accuracy at distance, but up close it makes those projectiles the closest thing to a grenade that you can load into a .22LR.
I wouldn't bet my life on a .22LR in wolf country, I'll put it that way.
-M