Most of the negative issues regarding long range hunting have been addressed through the new technology, and until whitetail deer stop being wounded by once a year hunters shooting from 50 yards with 15 year old ammo, there's little reason to criticize the dedicated long range hunter. Provided the long range hunter is willing to make the investment in the technology, and shoots enough at long range to master the art, and learns what the technology's won't/can't do, he's on the right track.
I think your greatest challenges will be similar to what I face here, wind and late winter or springtime mirage. If you purchase a scope with a Horus style reticle, and there's a book full of them to choose from, hold offs for wind and elevation can be made faster and more accurately than by adjusting the scope turrets. Each time you adjust the turret of your scope, there's a chance of a mechanical error, especially out near the limits of those adjustments, but holding off with a grid style reticle solves the problem. Get a good quality scope level, preferably one that folds to the side that you can easily see with your non-shooting eye, and get in the habit of using it. Canting is the most common reason for dumping a shot left or right. Placing a heavy pack against the front of the bi-pod legs will allow you to put greater load on them, without having them move on you just prior to the shot. At extreme ranges everything matters, so don't neglect punching in all the pertinent data when shooting beyond 1000, that can be ignored when shooting within a 1000.
Your .50 will work fine of course, and it sounds like you're excited about getting it. While I enjoy smacking steel way out there, my long range rig isn't suitable for big game, and I've made the decision that long range big game hunting isn't something I'll pursue. This isn't a criticism of those who do, but from my perspective, its an expensive endeavor to participate in, and I'm not so passionate in my desire to make long range hits on live targets that the expenditure is appropriate. Mind you, this winter I want to try hitting a 45 gallon drum at a mile. Its no longer an earth shattering accomplishment, but it should test the limits of my .308. Enjoy that rifle when it arrives.