I can't add much to our fellow from BC. I will say that the only .22 handgun that I plan to buy is either a K22/model17 or a 617. I've just not yet weighed in the pros cons of 6 shots and a light barrel versus 10 shots and a less desirable full lug barrel. Honestly, I'll probably go with the K22 in the end. It's just a matter of finding the right one.
I've never shot factory .357. I reload my own. Some factory .38 /158 that I shot recently has more go than my handloads for that, and my .357 isn't anywhere near max because I load for accuracy first, and use the faster powders currently, because I can't buy 2400 for love or money.
I will say that .357 is IMO the single best all around revolver cartridge for range fun. Recoil isn't punishing like the bigger bores get to be, and you can load it down to .38 special levels. For me it ranks up with 45ACP for enjoyment.
.38 target loads are powder puffs that seem closer to a .22 in some ways, but I've always enjoyed them.
My only real ding against .22 is that I get no instant feedback on how I'm shooting since I can't see the holes until I bring the target in.
PS - I'll always opt for adjustable sighted guns first, though I did use to own and shoot a Model 10 when I was younger, and had no issue with it.
I didn't like not being able to see where I landed on the paper target, so bought shoot n see stickers for like $9 and free shipping
http://www.amazon.ca/gp/product/B0000C51GH?psc=1&redirect=true&ref_=oh_aui_detailpage_o06_s00