I owned a African in .375 Ruger and have a good friend with an Alaskan in .416.
My 375 Ruger was super easy to load for (it shot everything well) and ballistics with a 260 grain AB were impressive. I sold it to buy a different rifle before I ever took any game with it.
I've shot my buddies 416 Alaskan a number of times. His was a little picky to find a load, but he did find a good one with the 350 grain TSX and it shoots well. He took a bear with it last fall. I like the Houge stock on the rifle, it's short, handy and weather proof. I think they are very practical rifles for hunting large game in areas with wet or harsh climates.