For home defense time typically is not on your side. Generally, the quicker you can grab and load the shotgun the better your chances of a positive outcome. With that in mind a box magazine fed shotgun seems the logical choice especially if retrieving and loading in reduced lighting type conditions while still adhering to storage laws.
I feel like this logic is flawed... leaving a box mag loaded (remember, speed is key) will distort the sheels and cause lots of stoppages and feed issues. If you wait until there is an intruder to load the mag, you've lost all advantages of the box mag and are not any faster then any other tube fed shotgun. I'll stick to my M4 Double tapping 00buck FTW