An individual has to choose the most effective defense package, taking into account both the expected terminal ballistics of the round and caliber he chooses and how well he shoots that pistol and ammunition combination. For example, if a person were trying to decide between shooting 9x19 or .40SW, he might:
from a holster, at 7 yards,
shoot ten rounds into an NRA-type pistol target as quickly as possible,
do this for both pistols, and
score the targets, scale the score to percent,
multiply the FBI wound volume for each round by the target's score, and
divide that by the time it took to shoot the rounds, starting from the holster.
This kind of a calculation is going to yield something like total wound volume (in cubic inches) per second. It will take into account if a person is slower and less accurate with a certain pistol and caliber, and it will take into account the terminal ballistics of the round.
The pistol and caliber with the highest score wins.