I own a P220 in .45ACP, and have +/- 5000 rounds through it. It is a great pistol. Simple, reliable, bloody expensive.
I am issued a DAO S&W 5946 at work, and have +/- 7500 rounds through it. It is mechanically complex, and heavy as a bloody boat anchor.
I may create quite a stir by saying this, but I am actually happier shooting the DAO than the TDA of the Sig, AND, the S&W has stopped precisely once on me, with a bad primer, whereas the Sig has stopped at least 5 times that often (Tongue in cheek - I bought .45 to reload, and had to make sure I was feeding the Sig stout enough rounds to get her to function properly!).
If I can convince the wife that I've been a good boy this year, I would like to try a .45 M&P, as a replacement for my Sig.
YMMV,
Happy Holidays