I voted for single shot but I must qualify this.
I would not hunt a grizzly/brown nor a polar bear with a single shot but would not hesitate to hunt anything else.
Not hunting dangerous game with a single shot is more psychological to me than actual experience.
I have done extensive practice loading and dry firing a single shot to the point that I can shoot as quickly as 5 seconds between rounds (requires a lot of practice) where if I dry fire a bolt action, the time will be between 2 and 4 seconds (take the safety off, aim and dry fire, eject the empty, load a new round, aim and then dry fire).
My dry firing exercise go from cocking my Encore Pro Hunter, dry firing it (including aiming at target), unloading it, retrieving a round from my round carrier on the butt stock, loading it and then dry firing it (again after aiming).
My concerns with a single shot would be for close shots on dangerous game. Your reloading process under a very stressful condition might not be as smooth as when just practicing.
For what it's worth, all my big game shot up to now required only one shot although I have taken a second shot on a moose as a precaution.... the first one had hit the vitals and caused extensive damage but it was just standing there not moving.
Duke1