I have found that most guys I know that are willing to shoot yotes with a .22LR don't care if they get a clean kill. They are just lobbing lead and laughing. It's just stupid.
Close range and a confident shot, then ya, I'll kill a yote every day of the week with a .22, but like most guys on here have said. If you're going out with the express purpose of killing yodel dogs, then get something bigger. 300 win-mag has been the most fun so far, but not cheap. But I'll throw away a buck or two to watch a running dog get damn near split in half. . .