Usually a bullet is specified for a specific cartridge because its designed to produce optimum terminal effects with a specific velocity envelope. You wouldn't expect a 170 gr .30/30 bullet to perform well if it was loaded on a .300 magnum for example. Similarly, provided you load the 160 gr 6.5 Carcano bullet on a cartridge with moderate case capacity rather than a .264 Winchester Magnum, you can expect good results. As a side note, too bad more bullet manufacturers don't recommend a velocity range for their bullets like Woodleigh does.