No. My Savage is zeroed for 25, and at 100. I'm aiming 8 or more inches to drop it at 100 to hit the plates. And at 50, I'm holding off a bit. Worked well for the last 2 club shoots. That I came 1st and 2nd.
Every gun is different, every ammo is different, no mention if its STD/Subsonic or HV.
Best thing you can do. Put a huge piece of fresh cardboard on the target stand, slap a target on it. That way you can see if it drops low, and know it is only your shots on target. Set target at 25, shoot, adjust and zero, and then walk it back each distance, shoot, adjust zero counting the clicks as you do, make a note.
I got to do that with a couple guns, as I just bought new optics for it, and my notes got water damaged.
I mean my aperture sight, I got hash marks for my 25, 50 and 100 yard zero. Also got notes on the side of the forearm on paper.
OP, the folks replying to you here are telling you their "personal experience" with their rifles for the most part.
You are definitely a newbie, to the shooting world and it's going to be a long learning curve.
Okay Shooter is giving you advice in "layman's terms" and it's good advice.
Most people have no idea what their 22 rimfire rifles are capable of at 100 yds because what they use them for usually happens under 50 yards, mostly under 25yds.
As such they often mount poor quality scopes, which will have set "parallax" distances, which will be right around 25 yards for most 22LR rated scopes.
Look up PARALLAX in your search engine. It's critical to shooting tiny groups if you're serious about accuracy.
Most 22LR rifles are very capable of shooting small groups at 100+ yards IF they are paired with ammunition they like, scopes capable of adjusting their "objective lens" to reduce or eliminate parallax at any distance, and even good "diopter" style iron sights as long as your eyes are capable.
The first thing is to find the type of ammunition your rifle prefers.
This isn't as easy as it sounds, and some folks pay a lot of money for high end match grade ammunition. They will pay more for a box of 50, than most will pay for a brick of 500.
They do this because that ammunition will shoot consistently from lot to lot, with no or minor adjustments to their scopes.
With most off the shelf generic brands of 22rf ammo, things can and often do change dramatically from brand to brand and lot to lot.
Most 22rf ammo is temperature sensitive as well. Shooting in the cool morning will give you different points of impact than during the hot afternoon, etc.
NOT ALL 22rf AMMUNITIO IS EQUAL.
You need to join a local club, if possible, and find a mentor. This may or may not be easy.
Usually it means going to the range, watching other shooters, "politely" asking a few questions, and as often as not, "someone" will help you walk through the beginning stages.
You're going to run across those that never shoot beyond 25 yards and those who shoot out past 100yds with 22rf.
Some folks are shooting what I would consider to be "unethical hunting distances" with 22rf out past 300 yds. Even gophers HURT when you gut shoot or otherwise wound them with bullets that don't have enough retained energy to ensure a clean kill.
Have fun and KEEP NOTES.
I don't purchase high end ammunition. I prefer to put the cash towards a rifle/scope combination I can trust to shoot most generic brands reasonably consistently, so when I run out of the case of 5000 I purchase, it's not a chore to sort through a bunch of different brands to get acceptable accuracy again.
Many 22rf rifles will not shoot "hot" ammo well. Some will shoot it extremely well.
Most Ruger 10/22 off the shelf rifles are not capable of "match" accuracy, without a lot of add ons, so don't expect great things from them if you have one. They're quite good for their intended purposes though and good value for many.
This is just a very basic start to the knowledge you will need if you decide to pursue "match accuracy" shooting with a 22lr, from 25 yards to 100yds and beyond.
A good place to start, with most rifles I've shot and started others on is CCI STANDARD VELOCITY ammunition, if you can find it. Most local gun shops and some big box stores carry it. It's seldom "on sale" and it's usually more expensive than most generic brands. There are a few semi auto types that it won't cycle.
If yo get lucky, you will find a guy like OkayShooter, and the others who posted here on the range, who has enough knowledge to help you get started on the right path.
Just remember, most shooters have only shot their own personal rifles, or maybe others which belong to friends. They don't have a wide range of experience, but may know the rifle they shoot very well. That doesn't mean what they know about their "personal" rifle will transpose to your personal rifle, but it will usually give you some good info.
D-5 measured at 0.947" Ctr-2-Ctr, and I have done a few 'better' groups of 5. But Not a lot 
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