First off, congrats all around, Tod. It seems that you and I are moving in opposite directions in our lives. You just got married and I just became single again

(The nasty process of this divorce explains my absence from this forum, and from the hunting fields, for the last eighteen months -- something I pray you NEVER have to experience!)
But we both have a deep love for the .300 Winchester Magnum. I agree that H4831SC is a classic powder choice, as is IMR 4831. One of these two always works.
In the last few years, I've become a convert to Vihtavuori N560 for hunting loads in the .300 Winchester Magnum and .30-06. It seems to have a burning rate nearly identical to Reloder 22, and it gives amazing velocities and accuracy. The downside is that it is hard to find and the most expensive powder you can buy.
I look forward to hearing your results at long range with the 200-grain TSX. My only concern with that bullet would be stabilization at long range. Those are long bullets. A few years ago I tried the Nosler 200 Accubonds out of my Sako, and they seemed to work OK at 100 metres, but accuracy fell off at 200. I chalked it up to the 1-10 twist and 2,850 velocity not giving enough spin to adequately stabilize those long bullets. I went down to the 180 Accubond (chronographed at 3,050 out of my 22-inch barrel), and it remains my standard hunting load to this day. I've shot one animal with it, and I can confirm that it hits HARD.
It's also interesting that you, of all people, are going to a heavy bullet in the TSX. I've lost count of the number of times that you've counseled people to go a little lighter with the Barnes bullets because they hold together so well so you don't need that extra weight for penetration. The recoil is also heavier with the 200-grain bullets than it would be with a 168, for example, and its questionable how much real-world advantage the 200 would give you in wind-bucking ability inside 600 yards (which is further than I'd shoot one of these bullets, anyway). At the longer ranges where impact velocities have dropped, the extra velocities of the 168 or 150 might be of assistance in ensuring that the bullet opens on impact.
All of this is just theoretical, though. Bravo for choosing something that you've thought through and played with. Keep us informed of your progress!