having shot a few 22cal chamberings, I have settled on the 223 and 22 CM. With the 223, it is an 8 twist and can easily toss 75gr ELDMs to 1200yds accurately. I have shot a ton of Hrn 80gr Amax back in the day with a 223 and chased 338LMs out to 1400yds, and even got some out to a mile. Right now, 50gr TNTs and 55gr hrn sps are loaded up for some PD hunting. Very versatile chambering.
For getting the most performance from the 22cal, I paired the 22 CM with the Sierra 95gr MK in a 7 twist around 2800/2900fps. This is near starting load territory (yes, you can do this with smaller cases at higher pressures) as I see no value in another 100fps, at a huge cost in bore life. I have gone to PRS competitions and done well with barrels in the low teens and seen excellent steel smashing performance in the high teens, low 2000's. I intentionally keep pressures low and barrels from overheating. Ballistics with this combo rivals larger magnums all the way to 1500+yds. I have tested the 22CM with 77gr to 90gr and they all have done well but it is really hard to beat the 95s when you want to reach out there in the winds.
If you throttle up the 22CM to reach the fastest speeds, bore life will be brief. I don't bother and barrels, which I have shot a number, seem to give me decent bore life vs the performance.
The biggest reason I stick with these 2 is brass.... availability and cost. and they also feed from the mags I have onhand. Yes, I have the bolt head for the PPC case but with components being so expensive and hard to find, ventures in the ARC and PPC don't interest me at this time. I have no interest in the BR cases after spending a few years using it (6BR was my first 'accurate' chambering) as mag feeding can be spotty and cases are pricey.
My other chambering is a 308win so you can see I lean heavily on ease of access, stability in supply and longevity of use. Did alot of boutique and wildcat chamberings over the decades. Fun and interesting if you haven't played but I have been there done that. A bit more this or that doesn't really mean much in real world shooting
YMMV
Jerry