I have a 2-yr old Ruger MKIII Std 6" and a 20-yr old S&W Model 17-6 6". The Ruger (now that it is broken in) is a great little gun. It eats just about any .22LR, its accurate, and reliable. My wife shoots better with it than I do. For cleaning, I don't bother to take it apart. Just dry patches thru the barrel via a wooden BBQ skewer, a few squirts of solvent, and a blast with the compressor at 100 psi, and a good wipe-down keeps it spic-and-span. I'd recommend it to anyone as a first semi-auto .22 pistol.
Saving the best til last, the S&W Model 17/K-22 is what I'd recommend if you want serious accuracy and reliability. Mine is super-accurate with Federal Champion copper-coated HP 525 rd bulk ammo, but shoots well with anything I put through it. Another nice thing about revolvers is being able to rotate the cartridge in the cyclinder to re-shoot misfires. So far, of the dozens of misfires I've tried for a 2nd time in my Model 17, only one has failed to fire.