OK. I have a 25-06 AI. Rem 700 custom. RKS 20X10:1 gain twist barrel. 120 gr bullets, 60.0 gr H1000, F210 primer, 3160 fps, brass life excellent. The improved version solves a lot of issues the standard case has. The standard 25-06 works brass forward into the neck area and every time the cartridge is fired, new load data is required to keep up with changing brass. My only problem with this rifle is the twist. I wish I would of had the brains to go with a 1:8 twist. I built a 25 WSSM with a 1:8 Pacnor barrel for 1000 yd BR shooting, 135 / 145 gr bullets in this rifle are awesome. I like 25 caliber rifles. Also have a 250-3000 AI, the 25 WSSM, and a new reamer waiting for a 1:7 bbl that will be a longer bodied-longer necked WSM case to shoot 150 gr. 25's.
R-22 is a superb powder and it develops high velocity, but it also develops a lot of heat. A couple rifles I tested this summer proved there are better choices. In a 7mm Rem Mag custom 65 gr of R-22 was showing great accuracy but after 3 quick shots the barrel was too hot to touch. Switching to 73.5 gr Retumbo increased velocity and shot strings of 10 rnds doesn't get barrel too hot to handle. My 6.5-284 and 6.5X55 were burning R-22 replaced with H4350. Better groups lower barrel temps.