The Speer manual 14 actually goes on a bit of a rant about how some people insist on using the round, and they only even print info for it because they thusly feel obligated. If you get the chance to read it, they really trash and heap scorn upon the little round. From a 2inch barrel, they get roughly 1000 fps, with a 35gr Gold Dot, and around 800fps with a 50gr FMJ.
I've also heard it said, that it one of the cruelest killing rounds there is, as it doesn't kill you right away, it lets you live long enough to die on the operating table 8 hours later. Definitely not a dependable stopping power defense round.