I'd go with the 300 H&H...but I'm biased because my old Rem 721 has never had to shoot anything more than once, no doubt more luck than skill, whether its been caribou in thr Yukon or Moose or Mule Deer in B.C. or Saskatchewan, even the occasional coyote, and I've found the 300 H&H very easy to load, consistently accurate...an awesome cartridge !